Murine models for the study of lung cancer have historically been the backbone of preliminary preclinical data to support early\nhuman clinical trials. However, the availability of multiple experimental systems leads to debate concerning which model, if any,\nis best suited for a particular therapeutic strategy. It is imperative that these models accurately predict clinical benefit of therapy.\nThis review provides an overview of the current murine models used to study lung cancer and the advantages and limitations of\neach model, as well as a retrospective evaluation of the uses of each model with respect to accuracy in predicting clinical benefit of\ntherapy. A better understanding of murine models and their uses, as well as their limitations may aid future research concerning\nthe development and implementation of new targeted therapies and chemotherapeutic agents for lung cancer.
Loading....